The sixth installment continues its first day of release in 4,275 domestic locations and will expand to 4,350 theaters on Friday.
Last month, Michael Bay's Transformers: Revenge of the Fallen grossed $16 million in midnight runs, also on a Wednesday.
"Half-Blood Prince" opened in the same Wednesday slot that Harry Potter and the Order of the Phoenix did in 2007. "Order of the Phoenix" grossed $12 million in midnight runs on its way to a $139.7 million five-day debut.
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